A Multi-Center, Double-Blind, Placebo-Controlled Phase II/III Study to Evaluate the Impact of Nasal-Inhaled Insulin in Participants with Mild Memory Impairment and Early Alzheimer's Disease (SNIFF)

What is the SNIFF Study?

The purpose of the SNIFF study is to find out whether insulin, when administered as a nasal spray, improves memory in adults with a mild memory impairment or Alzheimer's disease (AD).  The rationale behind the study is growing evidence that insulin carries out multiple functions in the brain and that poor regulations of insulin may contribute to the development of AD. Insulin resistance, reduced cerebrospinal fluid insulin levels, and reduced brain insulin signals have been found in AD patients, suggesting that a therapy aimed at correcting these deficiences may be beneficial.

A study flyer with more details is attached.